イェソング音?センタ?のキム?ヒョンテ院長は攣縮性??障害の原因を極めた?究論文を?際?術誌の中耳鼻咽喉科最高の?術誌のひとつである Acta Oto-Laryngologicaに???表しました.
本?究論文はキム?ヒョンテ院長が責任著者でカトリック大??科大?聖母病院に?授で在職する時施行した?究として審査過程を?って 2005年に採????されました.
?究論文の題目 : Neuroimmunological activation of the afferent laryngeal
neuronal circuit in experimentally induced laryngeal inflammation.
論文誌名 : Acta Oto-laryngologica, 2005; 125: 184-190
要約 :
Conclusions: These results show that laryngeal inflammatory reactions may induce the
expression of proinflammatory cytokines along the afferent laryngeal circuit and in nuclei
associated with the HPA axis. Local laryngeal inflammation may induce functional and
physiologic alterations in the laryngeal neural system via neuroimmunologic reactions.
Objective: Idiopathic laryngeal disorders associated with various neurologic conditions
such as spasmodic dysphonia, idiopathic vocal fold paralysis and sudden infant death
syndrome are causally related to upper respiratory tract infections, and it can be
speculated that these disorders result in neurophysiologic alterations. The goal of this
study was to identify the neurophysiologic effect on the central nervous system
of local inflammatory alterations in the larynx.
Material and methods: The expression of c-fos and IL-1β was identified after injecting
saline solution, 10 μg of lipopolysaccharide or 100 μg of lipopolysaccharide into the larynx of 12 rats.
Results: The inflammatory cytokine IL-1β was mainly expressed in the inferior olivary
nucleus and raphe nucleus, which are associated with the hypothalamic-pituitary-
adrenal (HPA) axis. IL-1β expression was also found in the nuclei of afferent nervous
pathways of the superior laryngeal nerve, such as the nucleus tractus solitarius,
nucleus ambiguus, lateral reticular nucleus, magnocellular reticular nucleus
and paragigantocellular reticular nucleus.
Keywords:
C-fos, hypothalamic-pituitary-adrenal axis, IL-1β, laryngeal neural pathways, laryngeal
reflex, larynx, nucleus tractus solitarius, proinflammatory cytokine