攣縮性??障害の病理?的?病記?を明かした?究論文を?際?術誌に?表 - 最新の研究活動

Conclusions: These results show that laryngeal inflammatory reactions may induce the 

expression of proinflammatory cytokines along the afferent laryngeal circuit and in nuclei 

associated with the HPA axis. Local laryngeal inflammation may induce functional and 

physiologic alterations in the laryngeal neural system via neuroimmunologic reactions.



Objective: Idiopathic laryngeal disorders associated with various neurologic conditions 

such as spasmodic dysphonia, idiopathic vocal fold paralysis and sudden infant death 

syndrome are causally related to upper respiratory tract infections, and it can be 

speculated that these disorders result in neurophysiologic alterations. The goal of this 

study was to identify the neurophysiologic effect on the central nervous system 

of local inflammatory alterations in the larynx.



Material and methods: The expression of c-fos and IL-1β was identified after injecting 

saline solution, 10 μg of lipopolysaccharide or 100 μg of lipopolysaccharide into the larynx of 12 rats.



Results: The inflammatory cytokine IL-1β was mainly expressed in the inferior olivary 

nucleus and raphe nucleus, which are associated with the hypothalamic-pituitary-

adrenal (HPA) axis. IL-1β expression was also found in the nuclei of afferent nervous 

pathways of the superior laryngeal nerve, such as the nucleus tractus solitarius, 

nucleus ambiguus, lateral reticular nucleus, magnocellular reticular nucleus 

and paragigantocellular reticular nucleus.





Keywords: 



C-fos, hypothalamic-pituitary-adrenal axis, IL-1β, laryngeal neural pathways, laryngeal 

reflex, larynx, nucleus tractus solitarius, proinflammatory cytokine